Staff >> Faculty >> Dr. E. Eunice Sindhuvi

Dr. E. Eunice Sindhuvi, MSc, PhD

Associates Professor, Haematology

Email: eunice@cmcvellore.ac.in

Career Interests

Haemoglobin E, Iron Metabolism

Research

No	Project Title	Funding Agency	Start Date	Duration
1	Are polymorphisms in iron regulatory genes responsible for phenotypic differences in iron metabolism? [Principal Investigator]	DBT	2010	3 Years
2	Transcriptional and translational processes of βE gene [Principal Investigator]	DBT	2009	3 Years
3	Molecular and Functional Evaluation of genes involved in iron absorption, transport and storage in the context of iron deficiency [Principal Investigator]	DBT	2008	3 Years
4	Molecular Mechanisms of Human Globin Gene Regulation [Co-Investigator]	DBT	2009	5 Years
5	Molecular Genetics of Hereditary Rare Bleeding Disorders in Indian Population [Co-Investigator]	DBT	2009	3 Years

Education

Duration	Description of Qualification	College/University
1993- 96	B.Sc (Bio-Chemistry)	V.V.V College for women, Virudhunagar. Madurai Kamaraj University, Madurai
1996-99	M.Sc (Medical Bio-Chemistry)	Christian Medical College, Vellore T.N.MGR Medical University, Chennai
2002 – 06	Ph.D “Molecular Genetics of Haemoglobin E”	Christian Medical College, Vellore T.N.MGR Medical University, Chennai

Positions

Institution Place	Position	From (Date)	To (date)
Christian Medical College, Vellore	Senior Demonstrator	21.12.2000	20.12.2003
Christian Medical College, Vellore	Lecturer Gr.III	21.12.2003	16.08.2006
Christian Medical College, Vellore	Lecturer Gr.II	17.08.2006	16.08.2009
Christian Medical College, Vellore	Lecturer Gr.I	17.08.2009	16.08.2011
Christian Medical College, Vellore	Assoc.Professor	17.08.2011	Till date

Seminars/Symposia/Awards

• Received a full EC Marie Curie Action Scholarship to attend the Second “ESH-CLUB DU GLOBULE ROUGE ET DU FER EUROCONFERENCE ON DISORDERS OF IRON HOMEOSTASIS, ERYTHROCYTES AND ERYTHROPOIESIS” held at Cascais, Portugal from Nov 10-12, 2006
• Cleared the CSIR-UGC Lectureship exam in June 1999

RECENT ABSTRACTS IN INTERNATIONAL MEETINGS

Fifth Meeting of the International BioIron Society, London 2013

• MOLECULAR ANALYSIS OF GROWTH DIFFERENTIATION FACTOR 15 IN ANEMIA OF PREGNANCY
  Rekha Athiyarath¹, Kalaiselvi Shaktivel¹, Daisy Singh² Vinod Joseph Abraham², Alok Srivastava¹ and Eunice Sindhuvi Edison¹
• ASSOCIATION OF SINGLE NUCLEOTIDE POLYMORPHISMS WITH TIBC AND ERYTHROCYTE COUNT IN IRON DEFICIENCY ANEMIA OF PREGNANCY IN INDIAN POPULATION
  Rekha Athiyarath¹, Kalaiselvi Shaktivel ¹, Daisy Singh², Vinod Joseph Abraham², Alok Srivastava¹ and Eunice Sindhuvi Edison¹

American Society of Hematology, Atlanta, USA, 2012

• Rekha Athiyarath, Ramachandran V Shaji, Rayaz Ahmed, Biju George, Vikram Mathews, Alok Srivastava, and Eunice Sindhuvi Edison High Expression of p53 and Growth Differentiation Factor-15 in Beta-Thalassemia.Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 2130
• Rekha Athiyarath, Neeraj Arora, Rayaz Ahmed, Biju George, Mammen Chandy, Alok Srivastava, and Eunice Sindhuvi Edison Molecular and Functional Characterization of Two Novel Missense Mutations in Iron Transport Protein Causing Hypochromic Microcytic Anemia and Hemosiderosis Blood (ASH Annual Meeting Abstracts), Nov 2012; 120: 3202

Contact Details

Dr. E. Eunice Sindhuvi, MSc, PhD Associate. Professor

Department of Haematology,
Christian Medical College,
Vellore- 632004, Tamil Nadu,
India.

Email: eunice@cmcvellore.ac.in
Phone: +91- (0)416-2283569/577

Publications

Journal Publications

• Rekha Athiyarath, Alok Srivastava, Eunice S Edison. Molecular basis of Primary Iron Overload in India and the role of serum derived factors in hepcidin regulation. Ann Haematol 2013 Jun;92(6):843-4
• Thiyagaraj Mayuranathan, Janakiram Rayabaram, Eunice S Edison, Alok Srivastava, Shaji R Velayudhan. A novel deletion of b globin promoter causing high HbA2 in Indian population. Haematologica. 2012 Sep; 97(9):1445-7. 
• Jain.S, Edison ES, Vikram Mathews, Shaji R.V. A novel δ globin gene mutation [HBD: c.323G>A] masking the diagnosis of β- thalassaemia: A first report from India. Int J Hematol. 2012 May; 95(5):570-2.
• Eunice.S.Edison, Sathya.M, Rajkumar.S.V, Sukesh.C.Nair Alok Srivastava and Shaji.R.V. A Novel b Globin Gene Mutation HBB.c.22 G>C produces a Hemoglobin Variant (Hb Vellore) Mimicking HbS in HPLC. Int J Lab Hematol. 2012 Oct;34(5):556-8
• Eunice.S.Edison,Rajkumar.S.V, Sankari Devi.G, Biju George, Shaji.R.V.  A novel 26 bp deletion [HBB: c.20_45del26bp] in exon-1 of the β globin gene causing thalassaemia major. Hemoglobin. 2012;36(1):98-102
• Eunice Sindhuvi Edison, Ramachandran.V.Shaji, Mammen Chandy, Alok Srivastava. Interaction of Hemoglobin E with other abnormal hemoglobins. Acta Haematol. 2011;126(4):246-8
• Preston FE, Lippi G, Favaloro EJ, Jayandharan GR, Edison ES, Srivastava A. Quality issues in laboratory haemostasis. Haemophilia. 2010 Jul;16 Suppl 5:93-9
• Edison ES, Athiyarath R, Rajasekar T, Westerman M, Srivastava A, Chandy M. A novel splice site mutation c.2278 (-1) G>C in the TMPRSS6 gene causes deletion of the substrate binding site of the serine protease resulting in refractory iron deficiency anaemia.Br J Haematol. 2009 Dec; 147(5):766-9.  
• Edison ES, Bajel A, Chandy M. Iron homeostasis: new players, newer insights. Eur J Haematol. 2008 Dec; 81(6):411-24.
• Eunice Sindhuvi Edison, Ramachandran.V.Shaji, Sankari Devi.G,  Anu Moses, Auro Viswabandhya, Vikram Mathews, Biju George, Alok Srivastava, and Mammen Chandy.  Analysis of b Globin Mutations in the Indian Population: Presence of Rare and Novel Mutations and Region Wise Heterogeneity. Clinical Genetics 2008 Apr;73(4):331-7.
• Edison ES, Melinkeri SR, Chandy M.  A novel missense mutation in glucose-6-phosphate dehydrogenase gene causing chronic nonspherocytic hemolytic anemia in an Indian family. Ann Hematol. 2006 Dec;85(12):879-80.
• Edison ES, Shaji RV, Srivastava A, Chandy M.  Compound heterozygosity for Hb E and Hb Lepore-Hollandia in India; first report and potential diagnostic pitfalls. Hemoglobin. 2005;29(3):221-4.
• Edison ES, Shaji RV, Srivastava A, Chandy M.  Hyperbilirubinemia in homozygous HbE disease is associated with the UGT1A1 gene polymorphism. Hemoglobin. 2005;29(3):189-95.
• Edison ES, Shaji RV, Devi SG, Kumar SS, Srivastava A, Chandy M.  Hb Showa-Yakushiji [beta110(G12)Leu-->Pro] in four unrelated patients from west Bengal. Hemoglobin. 2005;29(1):19-25.
• Shaji RV, Eunice SE, Baidya S, Srivastava A, Chandy M. Determination of the breakpoint and molecular diagnosis of a common alpha-thalassaemia-1 deletion in the Indian population. Br J Haematol. 2003 Dec;123(5):942-7.
• Shaji RV, Edison ES, Poonkuzhali B, Srivastava A, Chandy M.  Rapid detection of beta-globin gene mutations and polymorphisms by temporal temperature gradient gel electrophoresis. Clin Chem. 2003 May;49(5):777-81.
• Shaji RV, Edison ES, Krishnamoorthy R, Chandy M, Srivastava A.  Hb Lepore in the Indian population. Hemoglobin. 2003 Feb; 27(1):7-14.