Associate Professor, Haematology
Associate Professor, Haematology
Department of Biotechnology, Government of India
Department of Science and Technology, Government of India
Bayer Healthcare, USA
We are studying the molecular basis of rare coagulation deficiencies such as factor (F) I, prothrombin, F5, F5+F8, F7, F10, F11 and F13 deficiency and establishing algorithms for the genetic diagnosis in these conditions. In addition we are also elucidating the role of various molecular regulators of blood induced joint damage in preclinical models of haemophilia.
The collective experience with Adeno-associated virus (AAV) vector mediated human gene therapy trials so far, have clearly pointed to the need for substantial improvement in the efficiency of AAV mediated transgene expression as well as the need to attenuate the capsid-or transgene specific innate or adaptive immune responses against these vectors to achieve successful long-term gene transfer. Thus the research in this sub-theme is focused on dissecting out the biology of AAV life-cycle by understanding the interactions between AAV and various host cellular proteins, use this knowledge to design strategies to either augment the efficiency of gene transfer or intervene with (immune response) processes which are detrimental to AAV’s survival, yet maintain the safety of these interventionist strategies to the host cellular environment. These strategies are being simultaneously tested for their efficacy and safety in therapeutic models (Figure).
Degree |
Year |
Post-doctoral Fellow - 2007-2009, Dr Arun Srivastava’s Laboratory, Powell Gene Therapy Center, University of Florida, Gainesville, USA. |
2007-2009 |
PhD [Biomedical sciences/ Molecular Biology]-2008, T.N Dr. MGR Medical University, Chennai, India. |
2003-2008 |
M.Sc [Microbiology]- 1999, Madras University, Chennai, India. |
1997-1999 |
Year |
Professional Experience |
2013 |
Associate Professor, Department of Hematology, Christian Medical College, Vellore,India |
2012 |
Department of Hematology, Christian Medical College, Vellore, India |
2010 |
Adjunct Scientist, Center for Stem Cell Research, Christian Medical College, Vellore,India |
2008 - 2012 |
Lecturer/Assistant Professor, Department of Hematology, Christian Medical College, Vellore, India |
2007 - 2009 |
Post Doctoral Associate, Department of Pediatrics, University of Florida, Gainesville, USA |
2001-2008 |
Lecturer (MSc), Department of Hematology, Christian Medical College, Vellore, India |
Year |
Awards |
2014-17 |
Senior Innovative Young Biotechnologist award, Department of Biotechnology, Government of India |
2014 |
Young scientist award, YIM-MIT Boston, USA |
2012 |
DST travel award to attend American Society for Haematology meeting. |
2012 |
Swarnajayanti Fellowship award, Department of Science and Technology, Government of India |
2011 |
Innovative Young Biotechnologist award, Department of Biotechnology, Government of India |
2011 |
Eberhard Mammen Young Investigator award, Thieme Publishers. |
2010 |
Bayer Hemophilia Early Career Investigator Award, Bayer Inc, USA |
2009 |
Travel award, 12th American Society of Gene Therapy meeting, San Diego, USA |
2006 |
Overseas associate fellowship, Department of Biotechnology, Government of India |
2003 |
Aventis Travel grant, International Society of Thrombosis and Hemostasis XIX congress, Birmingham, U.K. |
1999 |
First rank in Madras University during Masters in Microbiology |
Year |
Recognitions |
2014-17 |
Invited Member, Hematology and immunology gene and cell therapy Committee, American Society of gene and Cell Therapy, Washington DC, USA. |
2011 - Present |
Invited Member, Laboratory Sciences Technical Committee, World Federation of Hemophilia, Montreal, Canada. |
Year |
Invited Talks |
2014, Mar-17 |
National Seminar on Biotechnology, Pondicherry University, Pondicherry. |
2014, Mar-14 |
School of Biological Sciences, Karunya University, Coimbatore |
2014, Feb-28 |
Plenary lecture, National Seminar on Stem Cells and tissue engineering, Vels University, Chennai. |
2014, Feb-25 |
School of Biotechnology and Technology, VIT University, Vellore |
2014, Feb-20 |
Stem Cell biology Seminar series, NiRRH - Mumbai. |
2014, Feb-19 |
NSF colloquium, TIFR-Mumbai |
2014, Jan-16 |
School of Engineering, Biotechnology / Bioengineering seminar, IIT - Kanpur |
2013, Dec-24 |
All India Cell Biology Conference, IISc, Bengaluru |
2013, Sep-30 |
Seminar in Biotechnology, KSR College, Tiruchengode |
2013, July-26 |
School of Biotechnology Research Seminar Series, VIT University |
2013, May-24 |
National Seminar on Drug discovery, JSS College, Ooty |
2013, May-18 |
National Seminar on Modern Biotechnology: concepts and practice, Madurai Kamaraj University |
2013, Apr-19 |
Musculoskeletal Congress, World Federation of Hemophilia, Chicago |
2013, Mar-27 |
Advanced School in Biomedical Nanotechnology, SASTRA University, Tanjore |
2012, July-9 |
Invited Chair on Session on genetics, World Federation of Hemophilia, Congress, Paris |
2012, Sep-10 |
Emerging trends in Cancer and Stem Cell biology, Bharathidasan University, Trichy |
2011, Nov-4 |
European Society of Hematology Annual Highlights meeting, Bangalore |
2011, Nov-11 |
Indian Society of Hematology and Blood Transfusion meeting, Chandigarh |
2010, Mar-2 |
Harvard University-NCBS Stem Cell Initiative, Bangalore |
2010, July 13 |
Hemophilia 2010 world congress, Buenos Aires |
2010, Nov-18 |
Indian Society of Hematology and Blood Transfusion meeting, Kolkata |
2006, May-21 |
Hemophilia 2006 world congress, Vancouver |
2004, Oct-20 |
Hemophilia 2004 world congress, Bangkok |
Year |
Honors |
2013 |
Oral presentation, International Society of Thrombosis and Hemostasis XXIV congress at Amsterdam, Netherlands |
2011 |
Oral presentation, 14th American Society of Gene and Cell Therapy meeting, Seattle, USA. |
2010 |
Oral presentation, 52nd Annual Meeting of the American Society of Hematology, Orlando, USA |
2009 |
Abstract achievement award and Oral presentation, 12th American Society of Gene Therapy meeting, San Diego, USA |
2008 |
Oral presentation, 11th Annual Meeting of the American Society of Gene Therapy, Boston, USA |
Year |
Professional Membership |
2011-present |
Member, International Society for Thrombosis and Hemostasis |
2010- present |
Member, European Society for Gene and Cell Therapy |
2010- present |
Indian Society for Hematology and Transfusion Medicine |
2007-present |
Member, American Society for Gene and Cellular Therapy |
2010 - present
Email:
jay@cmcvellore.ac.in
Phone: +91 416 2284118/3562
Allogeneic Stem Cell Transplantation forThalassemia Major. Hematol Oncol Clin North Am. 2014 Dec;28(6):1187-1200. doi: 10.1016/j.hoc.2014.08.009. Mathews V, Srivastava A, Chandy M. Epub 2014 Sep 22. Review. PubMed PMID: 25459187.