Chromosomes from a patient with a congenital form of bone marrow failure, Fanconi anemia, are sensitive to clastogenic agents (chemicals causing DNA breakage). This test is used to diagnose this condition.
Allogeneic Stem Cell Transplantation forThalassemia Major. Hematol Oncol Clin North Am. 2014 Dec;28(6):1187-1200. doi: 10.1016/j.hoc.2014.08.009. Mathews V, Srivastava A, Chandy M. Epub 2014 Sep 22. Review. PubMed PMID: 25459187.